Improving efficiency in a hybrid warehouse: a case study

Logistics has assumed a determining position in the supply chain of each organization. This paper concerns the work carried out in a bus manufacturing organization with the aim of improving efficiency in its hybrid warehouse. A hybrid warehouse could be considered as one that mixes several different activities (reception, storage area, picking, shipping, supply to production lines and production preparation tasks) and brings together many different materials or raw materials and components. This factor led to the appearance of innumerable management methods to improve employee performance. These are intended to meet the needs of their customers, from the motto "do more with less". The work developed in a hybrid warehouse allows to detect logistic complaints related to communication failures between employees, the reduced efficiency in the activities like the check of raw materials or components and respective picking, the lack of space for their reception and storage, and the non-compliance of the FIFO stock management system. It is imperative that organizations can redefine internal spaces and flows, generating a more efficient and intuitive work and admit an opportunity for improvements in terms of space and content management, and hence, cost savings for an organization. The combination of Lean tools was implemented, and the results have been checked, showing a significant impact in the hybrid warehouse, with annual gains through the optimization of several activities: employee turnover (decrease by 50%), check and picking times (decrease about 75 minutes/picking) and better working conditions for employees.info:eu-repo/semantics/publishedVersio

HARMONIZAÇÃO ESTÉTICA DO SORRISO COM FACETAS DIRETAS EM RESINA COMPOSTA

Composite resins are highly versatile materials that enable various applications in the field of aesthetic adhesive dentistry. Among its clinical indications the making of direct facets in the anterior superior teeth has been emphasizing, since it effectively corrects asymmetries and colorations. It is therefore a lower cost patient procedure compared to indirect facets, as well as aesthetic performance, predictability and longevity of clinical success. This work aimed to report the clinical case of a patient with aesthetic alteration in the anterior superior teeth: severe central incisor pigmentation and lateral rotation, and dental disproportionality. The technique of mock up diagnostic waxing was used to compose the planning of direct facets in the respective anterosuperior teeth mentioned in composite resin. The use of the direct facets in composite resin demonstrated the quality of this material and its high versatility, which allows the dental surgeon to use it in several procedures. It was possible to correct the color, shape, alignment and function of the restored teeth, resulting in an improvement in the patient's self-esteem and quality of life.As resinas compostas são materiais altamente versáteis que possibilitam diversas aplicações no campo da odontologia adesiva estética. Dentre suas indicações clínicas a confecção de facetas diretas nos dentes anterossuperiores vem se destacando, visto que corrige de forma eficaz assimetrias e colorações. Trata-se, portanto, de um procedimento de menor custo ao paciente em comparação às facetas indiretas, bem como alta performance estética, previsibilidade e longevidade de sucesso clínico. Este trabalho objetivou relatar o caso clínico de uma paciente com alteração estética nos dentes anterossuperiores: severa pigmentação dos incisivos centrais e giroversão dos laterais, além de desproporcionalidade dentária. Utilizou-se a técnica de enceramento diagnóstico com mock up para compor o planejamento de facetas diretas nos respectivos dentes anterossuperiores citados em resina composta. O emprego das facetas diretas em resina composta demonstrou a qualidade que este material possui e a sua alta versatilidade, o que permite ao cirurgião-dentista utilizá-lo em diversos procedimentos. Foi possível a adequada correção de cor, forma, alinhamento e função dos dentes restaurados, resultando em uma melhora da autoestima e qualidade de vida da paciente

Glycoengineered nanoparticles enhance the delivery of 5-fluoroucil and paclitaxel to gastric cancer cells of high metastatic potential

Gastric cancer is the third leading cause of cancer-related death worldwide, with half of patients developing metastasis within 5 years after curative treatment. Moreover, many patients cannot tolerate or complete systemic treatment due severe side-effects, reducing their effectiveness. Thus, targeted therapeutics are warranted to improve treatment outcomes and reduce toxicity. Herein, poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with 5-fluorouracil (5-FU) and paclitaxel were surface-functionalized with a monoclonal antibody targeting sialyl-Lewis A (sLeA), a known glycan mediating hematogenous metastasis. Nanoparticles, ranging from 137 to 330 nm, enabled the controlled release of cytotoxic drugs at neutral and acid pH, supporting potential for intravenous and oral administration. Nanoencapsulation also reduced the initial toxicity of the drugs against gastric cells, suggesting it may constitute a safer administration vehicle. Furthermore, nanoparticle functionalization significantly enhanced targeting to sLeA cells in vitro and ex vivo (over 40% in comparison to non-targeted nanoparticles). In summary, a glycoengineered nano-vehicle was successfully developed to deliver 5-FU and paclitaxel therapeutic agents to metastatic gastric cancer cells. We anticipate that this may constitute an important milestone to establish improved targeted therapeutics against gastric cancer. Given the pancarcinomic nature of the sLeA antigen, the translation of this solution to other models may be also envisaged.publishe

SEED GERMINATION AND SEEDLING DEVELOPMENT IN THE BROCCOLI IN FUNCTION OF DIFFERENT SUBSTRATES AND TEMPERATURES

This study aimed to evaluate the seed germination and seedling development of broccoli in function of different substrates and temperatures. The work was accomplished in the Laboratory of Technology and Analyses of Seeds at the Agrarian Science Center at the Universidade Federal do Espírito Santo (CCA-UFES), Alegre-ES, Brazil. A completely randomized design was used with four replications of 25 seeds, in a 2 x 6 x 4 factorial outline, with two lots, six substrates (Plantmax® (S1); Plantmax®+Fertium® 1 g dm-3 (S2); Plantmax®+Fertium® 2 g dm-3 (S3); soil+sand+manure (S4); soil+sand+manure+Fertium® 1 g dm-3 (S5); soil+sand+manure+Fertium® 2 g dm-3 (S6), and four temperatures (20 ºC, 25 ºC, 30 ºC and 20-30 ºC). For seed germination and initial development of broccoli seedlings can be utilized the substrate Plantmax® and Plantmax® enriched with Fertium®. The better percentages of germination occurred by using temperature of 25 ºC.No presente trabalho objetivou-se avaliar a germinação da semente e o desenvolvimento inicial da plântula de brócolos em função de substratos e temperaturas. O trabalho foi realizado no Laboratório de Tecnologia e Análises de Sementes do Centro de Ciências Agrárias da Universidade Federal do Espírito Santo (CCA/UFES), em Alegre-ES, Brasil. O delineamento experimental utilizado foi inteiramente ao acaso, com quatro repetições de 25 sementes por tratamento, em um esquema fatorial 2 x 6 x 4 (dois lotes de sementes, seis substratos e quatro temperaturas).  Os substratos utilizados foram: Plantmax® (S1); Plantmax®+Fertium® 1 g dm-3 (S2); Plantmax®+Fertium® 2 g dm-3 (S3); solo+areia+esterco (S4); solo+areia+esterco+Fertium® 1 g dm-3 (S5); solo+areia+esterco+Fertium® 2 g dm-3 (S6). As temperaturas testadas foram 20 ºC, 25 ºC, 30 ºC, 20-30 ºC. Para a germinação das sementes e o desenvolvimento inicial das plântulas de brócolos devem ser utilizados os substratos Plantmax® e Plantmax® enriquecido com Fertium®.  A temperatura 25 ºC é a recomendada para a germinação de sementes de brócolos

Quelques Aspects du Role du Programme Tempus dans l'Internationalisation de l'Enseignement Supérior.

L’expérience de l’Institut Universitaire de Technologie (I. U. T.) de Béthune (Université d’Artois) dans le programme Tempus-Phare provient de son activité depuis le 1er septembre 1991 dans 17 projets différents générant un budget global d’environ 5 millions d’ECU

Efeito de diferentes doses de Fe em solução nutritiva no desenvolvimento da raiz primária de trigo

Seven wheat (Triticum aestivum L.) cultivars were studied regarding Fe toxicity using five different levels of this element (0.56; 5.0; 10.0; 20.0 and 40.0 mg/l) in nutrient solution with aeration, under constant temperature (250 ± 1°C) and pH 4.0. The source of Fe was Fe2(SO4)3, 4H2O. Tolerance was measured by the mean of the primary root length of 20 seedlings grown during 10 days in nutrient solutions with different Fe concentrations. The cultivars BH-1146 and IAC- 17 showed the largest root growth when the concentration of 0.56 mg of Fe3+/l was used in the solution. The cultivar BH-1146 different from the cultivars CNT-8, IAC-5, Alondra-S-46, IAC-24 and Siete Cerros, but did not show significant difference from the cultivar IAC-17. The cultivar IAC-24 presented the shortest roots in this Fe concentration, being significantly different from the other cultivars. As the Fe concentration in the solutions was increased from 0.56 to 40.0 mg/l, reductions in root length were observed according to the degree of tolerance of each cultivar. Cultivars CNT-8 and Siete Cerros were considered tolerant to the increasing levels of Fe in the nutrient solutions, and cultivars IAC-5, IAC-17, Alondra-S-46 and IAC-24 were considered sensitive. The P, K and Ca concentrations decreased in the shoot as the levels of Fe increased in the nutrient solutions. Fe and Mg concentrations in the leaves increased in all cultivars as the levels of Fe increased in the nutrient solution.Foi estudado o comportamento diferencial de sete cultivares de trigo, (Triticum aestivum L.) em soluções nutritivas com arejamento, contendo cinco concentrações de Fe3+ (0,56; 5,0; 10,0; 20,0 e 40,0 mg/litro), mantendo-se constante a temperatura de 250 ± 1°C e o pH das soluções 4,0. A fonte de Fe3+ foi Fe2(SO4)3. 4H2O. A tolerância foi avaliada pelo comprimento médio da raiz primária central de 20 plântulas cultivadas durante dez dias, em soluções nutritivas contendo diferentes concentrações de Fe. As cultivares BH-1146 e IAC-17 foram as que apresentaram maior crescimento das raízes quando se utilizou a concentração de 0,56 mg de Fe3+/litro. A cultivar BH-1146 diferiu das cultivares CNT-8, IAC-5, Alondra-S-46, IAC-24 e Siete Cerros, porém não apresentou diferença significativa da cultivar IAC-17. A cultivar IAC-24 foi a que apresentou raízes mais curtas nessa concentração de Fe, diferindo significativamente das demais. À medida que foram aumentadas as concentrações de Fe de 0,56 para 40,0 mg/litro nas soluções, ocorreram reduções nos comprimentos das raízes segundo o grau de tolerância de cada cultivar. As cultivares CNT-8 e Siete Cerros foram consideradas tolerantes aos níveis mais elevados de Fe nas soluções, e IAC-5, IAC-17, Alondra-S-46, BH-1146 e IAC-24, sensíveis. Os teores de P, Ca e K na matéria seca da parte aérea tenderam a diminuir como aumento das concentrações de Fe nas soluções. Os teores de Fe e Mn na matéria seca da parte aérea elevaram-se com o aumento das concentrações de Fe nas soluções

Pedogênese e classificação de latossolos desenvolvidos de itabiritos no Quadrilátero Ferrífero, MG

Localizado na porção centro-oeste do Estado de Minas Gerais, o Quadrilátero Ferrífero abrange uma área de aproximadamente 7.000 km2. Desde o século XVII, a região é conhecida como uma província aurífera e ferrífera, sendo por essa razão uma das regiões mais bem estudadas do Brasil no contexto geológico. A região é de topografia muito acidentada, onde predominam solos pouco evoluídos pedogeneticamente, com destaque para Cambissolos Háplicos, Neossolos Litólicos e Neossolos Regolíticos. Em menor proporção e em rampas de colúvio (relevo suave ondulado), ocorrem Latossolos Vermelhos muito ricos em Fe, anteriormente denominados Latossolos Ferríferos. Neste trabalho, foram realizados estudos para caracterizar física, química e mineralogicamente amostras de nove perfis de Latossolos Vermelhos férricos e perférricos, desenvolvidos de itabirito e rochas afins no Quadrilátero Ferrífero, com os objetivos de melhor entender sua gênese e avaliar critérios taxonômicos que permitam sua diferenciação no SiBCS, em níveis categóricos mais baixos. Os elevados valores de densidade de partículas são peculiares nesses solos e, ao lado da estrutura forte, muito pequena e granular, são fatores que contribuem para subestimar os teores de argila e superestimar os de silte, resultando em relação silte/argila maior do que aquela proposta pelo SiBCS para os Latossolos. A variação dos teores de SiO2, Fe2O3, Al2O3, TiO2, MnO, P2O5 e de alguns elementos-traço aponta para a diversidade na composição química do itabirito ou, ainda, provável mistura com rochas filíticas da região. Os valores das relações Fe2O3/TiO2 (não molecular) e TiO2/Fe2O3 (molecular) revelaram-se diferentes daqueles sugeridos na literatura para separação de Latossolos Vermelhos desenvolvidos de itabirito daqueles de rochas máficas. As frações areia, silte e argila apresentaram grande variação na atração magnética, com as duas primeiras frações evidenciando maior magnetização, em razão da presença de magnetita. Os valores de substituição isomórfica de Fe por Al variaram 0,07 a 0,11 e 0,09 a 0,38 mol mol-1 nas estruturas da hematita e magnetita, respectivamente.Located in the Midwest of the State of Minas Gerais, a region called Quadrilátero Ferrífero covers an area of approximately 7,000 km2. Since the seventeenth century, it is known as gold- and iron-producing province, and the geological context is therefore one of the best-studied of Brazil. The regional topography is very rugged, with mostly poorly developed pedogenesis, especially Cambissolos Háplicos, Neossolos Litólicos and Neossolos Regolíticos. In a smaller proportion and on colluvial ramps (hilly relief), very Fe-rich Latossolos Vermelhos occur, formerly Latossolos Ferríferos. This study characterized the physical, chemical and mineralogical properties of samples from nine ferric and hyperferric Latossolo Vermelho profiles, developed from itabirite and related rocks in the Quadrilátero Ferrífero, with the objectives of improving the understanding of their genesis and establish taxonomic criteria for their differentiation in the SiBCS at lower categorical levels. The high particle density values in these soils are peculiar and along with the strong, very small and granular structure, are factors that contribute to underestimate clay and overestimate silt, resulting in a higher silt/clay ratio than proposed by SiBCS for Latossolos. Variations in the levels of SiO2, Fe2O3, Al2O3, TiO2, MnO, P2O5, and of some trace elements indicate the diversity in the chemical composition of itabirite or a probable mixture with phyllitic rocks of the region. The ratios of Fe2O3/TiO2 (non-molecular) and TiO2/Fe2O3 (molecular) reported in the literature for separation of Latossolos Vermelhos differed between soils developed from itabirite and from mafic rocks. The magnetic attraction in sand, silt and clay varied greatly; due to the presence of magnetite, magnetization was higher in the former two fractions. The values of isomorphic Al-for-Fe substitution ranged from 0.07 to 0.11 and from 0.09 to 0.38 mol mol-1 in the structures of hematite and magnetite, respectively

Crescimento, partição de biomassa e fotossíntese em plantas jovens de Genipa spruceana submetidas ao alagamento

Genipa spruceana Steyerm (Rubiaceae) is a species often found in flooded environments in the central Amazonia. The objective of this study was elucidate possible adaptive strategies that enable this species to occupy environments under flooding, targeting the potential of the species for restoration of floodplains. In order to achieve these objectives growth traits, number of leaves, leaf expansion, biomass production, carbon assimilation and stomatal conductance were investigated in G. spruceana seedlings subjected to treatments: 1- Non flooded plants (control -SA), 2- partially flooded (PA) and 3- completely flooded (TA) up to 90 days. Flooded treatments (PA and TA) induced smaller increments in all variables of height and diameter growth when compared to the control treatment. With increase of flooding, biomass allocation to leaves decreased until complete leaf abscission in TA, while increased in the stem. In PA treatment was observed reduction in C assimilation rates of 58% and 64% after 60 and 90 days, respectively, and 96% after 60 days in TA treatment. However, in the end of the experiment all treatments presented 100% of survival. Our results indicate that the loss of leaves and gain of the stem biomass can be protective strategy to alleviate the harmful effects of the flooding. On the other hand, the maxim survival rates suggest that G. spruceana exhibit high potential for establishment in frequently flooded areas